遗传代理的生物衰老与增生性疤痕/瘢痕疙瘩风险：一项探索性两样本孟德尔随机化研究

2026-07-14 · 论文 · upload

文献

摘要

该研究使用两样本孟德尔随机化方法，探究多种遗传代理的生物衰老指标与增生性疤痕（HS）风险之间的潜在因果关系。研究发现，遗传预测的更高IEAA和PhenoAge与HS风险降低存在名义上的关联，且PhenoAge的关联在独立验证队列中得到重复。多变量MR表明PhenoAge的保护作用独立于经典纤维化通路。

更多摘录

Genetically predicted higher IEAA...and higher PhenoAge...were nominally associated with a decreased risk of HS...This MR study provides exploratory evidence suggesting that genetically proxied faster epigenetic aging may be nominally associated with a reduced risk of HS