BHLHE40/DEC1 programs epidermal Langerhans cell identity.
2026-07-23 · 论文 · upload
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摘要
Langerhans cells (LCs) are long-lived, tissue-resident mononuclear phagocytes that form dense networks in stratified epithelia and migrate to draining lymph nodes to maintain immune tolerance. LC development and their immature epithelial identity depend on TGF-β family signaling, however the transcriptional effectors downstream of this pathway remain incompletely defined.